| Primary Identifier | IPR017421 | Type | Family |
| Short Name | MAPKKK7 |
| description | This entry represents mitogen-activated protein kinase kinase kinase 7 (MAP3K7, also known as TAK-1), which is a component of a protein kinase signal transduction cascade, acting as a mediator of TGF-beta signal transduction. MAP3K7 stimulates NF-kappa-B (NFKB) activation and the p38 MAPK pathway through the phosphorylation and activation of several MAP kinase kinases []. MAP3K7 binds both upstream activators and downstream substrates in multi-molecular complexes. This entry also includes the C. elegans human homologue MOM-4 [], which is part of the Wnt signaling pathway, essential for cell fate specification during embryo development.A small deletion of MAP3K7 and four other genes was found to be strongly associated with high-grade prostate cancers []. |
