| Primary Identifier | IPR030444 | Type | Family |
| Short Name | Liprin-beta |
| description | This entry represents liprin-beta mostly from invertebrates. Drosophila liprin-beta interact with liprin-alpha and is required for NMJ (neuromuscular junction) growth []. C. elegans liprin-beta, also known as hlb-1, or liprin-beta homolog, is a regulator for the organisation and function of neuromuscular junctions []. Hlb-1 may be involved in the ageing control in C. elegans [].Liprin was originally identified as binding partners of the receptor protein tyrosine phosphatase LAR (leukocyte common antigen-related), which functions in axon guidance and mammary gland development []. In vertebrates, there are two families of liprins, liprin-alpha and liprin-beta, which have four (alpha1-4) and two (beta1-2) members. In C. elegans and Drosophila, there are only one liprin-alpha (known as Syd-2 and Dliprin-alpha) and one liprin-beta. Another liprin family member, liprin-gamma, has also been identified in Drosophila []. Liprins contain an N-terminal coiled-coil domain and a C-terminal liprin homology (LH) region comprised of three sterile alpha motif (SAM) domains []. The N-terminal coiled coils of liprin-alpha mediate interactions with adapter proteins at the presynaptic active zone, while the SAM repeats bind proteins such as LAR receptor tyrosine phosphatase []. |
