| Primary Identifier | IPR044885 | Type | Homologous_superfamily |
| Short Name | PRESA_N_sf |
| description | This superfamily represents the N-terminal domain of RESA (ring-infected erythrocyte surface antigen) from Plasmodium falciparum, the apicomplexan parasite that causes the most severe form of malaria in humans.The short, four-helical domain first identified in the Plasmodium export proteins PHISTa and PHISTc []has been identified in the P. falciparum-specific RESA-type (Ring-infected erythrocyte surface antigen) proteins in association with the DnaJ domain. Overall, at least 67 proteins have been detected in P. falciparum with complete copies of the PRESAN domain. No versions of this domain were detected in other apicomplexan genera, suggesting that the domain was 'invented' after the divergence of the lineage leading to the genus Plasmodium undergoing a dramatic proliferation only in P. falciparum. The structure of this domain has been solved. It contains a short initial helix (α1) followed by an antiparallel bundle of 3 long helices (α2-α4) []. |
