| Primary Identifier | IPR029246 | Type | Family |
| Short Name | TALPID3 |
| description | TALPID3 is the name of a classical chicken mutant with abnormal limb patterning and malformations in other regions of the embryo. It was so called because their paddle-shaped limbs resemble those of the mole (Talpa) []. Besides the limbs, there is a set of malformations including face, skeleton, and vascular defects []. TALPID3 gene was then identified and found to be a target for Hedgehog signalling []. In chickens, TALPID3 protein is a centrosomal protein required for the function of both Gli repressor and activator in the intracellular Hedgehog pathway []. Similar to the chicken TALPID3 mutants, the mouse mutants also lack primary cilia and have face and neural tube defects. Moreover, it has defects in left/right asymmetry []. |
