| Primary Identifier | IPR042299 | Type | Homologous_superfamily |
| Short Name | Ufd1-like_Nn |
| description | This entry includes Ubiquitin fusion degradation protein Ufd1 from fungi and Ufd1-like proteins from animals and plants. Ufd1 is part of the Ufd1-Npl4 complex that functions as the substrate-recruiting cofactor for Cdc48 segregase. The Cdc48-Ufd1-Npl4 complex is involved in degradation of misfolded ER proteins []. The Ufd1-Npl4 complex has been found to recruit Cdc48 to ubiquitylated CMG (Cdc45-MCM-GINS) helicase at the end of chromosome replication, thereby driving the disassembly reaction [].In humans, Npl4-Ufd1 acts as a cofactor in reducing antiviral innate immune responses by facilitating proteasomal degradation of RIG-I (a viral RNA sensor) []. The Ufd1 N-terminal fragment is composed of two readily identifiable subdomains designated as Nn and Nc subdomains. The Nn subdomain adapts a double-psi beta barrel fold, and the Nc subdomain has a mixed alpha/beta roll structure []. This superfamily represents the Nn domain found in Ufd1 proteins. |
