| Primary Identifier | IPR007902 | Type | Family |
| Short Name | Chl4/mis15/CENP-N |
| description | This family includes Chl4 from budding yeasts, mis15 from fission yeasts and centromere protein N (CENP-N) from animals. In Saccharomyces cerevisiae, Chl4 is an outer kinetochore structural component required for chromosome stability []. Chl4 is a component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p []. It is required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation []. In Schizosaccharomyces pombe, mis15 is a subunit of the Sim4 complex, which is required for loading the DASH complex onto the kinetochore via interaction with dad1 []. It is required for correct chromosome segregation where it has a role in the formation and/or maintenance of specialised chromatin at the centromere []. In humans, centromere protein N (CENP-N) is a component of the CENPA-NAC (nucleosome-associated) complex, which plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation []. CENP-N localises exclusively in the kinetochore domain of centromeres []. It is required for chromosome congression and efficiently align the chromosomes on a metaphase plate []. |
