| Primary Identifier | IPR044933 | Type | Homologous_superfamily |
| Short Name | DIA_GBD_sf |
| description | This superfamily contains the N-terminal domain of diaphanous, a subclass of formins whose members are regulated by the binding of a small GTP-binding protein of the Rho subfamily. These proteins are characterised by a variety of shared domains: an N-terminal GTPase-binding domain (GBD), formin-homology domains FH1, FH2 and FH3, and a C-terminal conserved Dia-autoregulatory domain (DAD) that binds the GBD. This N-terminal domain corresponds to the GBD, a bifunctional autoinhibitory domain that interacts with and is regulated by activated Rho family members. Mammalian Drf3 contains a CRIB-like motif within its GBD for binding to Cdc42, which is required for Cdc42 to activate and guide Drf3 towards the cell cortex where it remodels the actin skeleton [, ]. |
