| Primary Identifier | IPR032949 | Type | Family |
| Short Name | SIX3/SIX6 |
| description | The human SIX protein family consists of six members (SIX1-SIX6), all of which contain two protein domains: a DNA binding homeobox domain and a SIX domain, which binds downstream effector molecules. They are thought to be transcription factors required for proper eye development [].This entry includes Homeobox proteins SIX3 and SIX6.SIX3 is a transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on target genes. During brain development, it maintains anterior forebrain identity and is required for neuroretinal specification and ependymal cell maturation []. It is also involved in eye development [, ]and pituitary development []. |
