| Primary Identifier | IPR029342 | Type | Domain |
| Short Name | ECIST_C |
| description | Activation of NF-kappaB as a consequence of signalling through the Toll and IL-1 receptors is a major element of innate immune responses. ECSIT (Evolutionarily conserved signaling intermediate in Toll pathway) plays an important role in signalling to NF-kappaB, functioning as an adapter protein of the Toll-like and IL-1 receptor signalling pathway and an intermediary in the signalling pathways between TRAF-6 and MEKK-1 []. It is part of the MCIA (mitochondrial complex I intermediate assembly) complex, involved in the assembly of mitochondrial complex I [].This entry represents the C-terminal domain of ECSIT, which is missing in isoform 2. This domain may be distantly homologous to the pleckstrin homology domain. |
