Primary Identifier | IPR017362 | Type | Family |
Short Name | DNA-bd_RFXANK |
description | This group represents the DNA-binding protein RFXANK which activates transcription from class II MHC promoters, requiring the activity of the MHC class II transactivator/CIITA. Deficiency is the commonest cause of bare lymphocyte syndrome (the absence of MHC class II transcription and humoral- and cellular-mediated immune responses to foreign antigens) [, ]. |