Primary Identifier | IPR030326 | Type | Family |
Short Name | Mucdhl |
description | Cadherin-related family member 5 (also known as Mucin and cadherin like, Mucdhl or MUPCDH) belongs to the protocadherins subgroup of the cadherin superfamily, whose members are membranous glycoproteins mediating Ca2+-dependent cell-to-cell adhesion []. The Mucdhl gene encodes several splicing isoforms that are mostly expressed in the kidney, liver, and gut [, , ]. Mucdhl is associated with Cdx2 and beta-catenin, and is linked to colorectal carcinogenesis []. It interacts with PCDH24 and plays a role in the brush border assembly [].This entry also includes cadherin-86C from the fruit fly Drosophila melanogaster. |