| Primary Identifier | IPR006353 | Type | Family |
| Short Name | HAD-SF_hydro_IIA_CECR5 |
| description | This family is a member of the Class IIA subfamily of the haloacid dehalogenase superfamily of aspartate-nucleophile hydrolases. Sequences in this family are all from eukaryotes. One sequence is called "Cat Eye Syndrome critical region protein 5"(CECR5) []. This gene has been cloned from a pericentromere region of human chromosome 22 believed to be the location of the gene or genes responsible for Cat Eye Syndrome. This is one of a number of candidate genes. The Schizosaccharomyces pombe (Fission yeast) sequence is annotated as "phosphatidyl synthase,"however this is due entirely to a C-terminal region of the protein (outside the region of similarity covered by this entry) which is highly homologous to a family of CDP-alcohol phosphatidyltransferases. The physical connection of the phosphatidyl synthase and the HAD-superfamily hydrolase domain in S. pombe may, however, be an important clue to the substrate for the hydrolases in this group. |
