| Primary Identifier | IPR029608 | Type | Family |
| Short Name | Cep63 |
| description | Centriole amplification is controlled by two duplicated genes, Cep63 and Deup1. Cep63 regulates mother-centriole-dependent centriole duplication, whereas Deup1 governs deuterosome assembly for large-scale de novo centriole biogenesis in vertebrate multiciliate cells [].Cep63 functions to ensure that centriole duplication occurs reliably in dividing cells. It interacts and cooperates with Cep152. Both proteins are dependent on one another for centrosomal localisation []. Cep57-Cep63-Cep152 form a ring-like complex that localises around the proximal end of centrioles []. Cep63 recruits Cdk1, which is essential for mitotic entry, providing a link between the centrosome and the cell-cycle machinery []. |
