| Primary Identifier | IPR005696 | Type | Family |
| Short Name | MesE/LcnD |
| description | Bacteriocins are antibacterial proteinaceous compounds produced by bacteria. In Gram-positive bacteria, they are divided into four classes. Within the class II, constituted by non-modified peptides produced mainly by lactic acid bacteria, bacteriocins of the subclass IIa (also known as pediocin-like bacteriocins), such as mesentericin Y105, are of particular interest. They are active against the foodborne pathogen Listeria monocytogenes and share a similar primary structure, with a conserved N-terminal motif (YGNGV). Subclass IIa bacteriocins induce membrane permeabilization of sensitive strains []. Class-IId contains the one-peptide non-cyclic bacteriocins that show no sequence similarity to the pediocin-like bacteriocins, and include lactococcin A (LcnA) [].The translocation of most of the class II bacteriocins requires a type I secretion system which is composed of maturation and secretion protein and an accessory factor. MesD and MesE encode the dedicated transport system of mesentericin Y105 []. Secretion and maturation of LcnA depends on the two membrane proteins LcnC and LcnD []. This family consist of accessory factors such as MesE and LcnD. Their function remains unclear, but they are required for full production of these bacteriocins [, ]. |
