| Primary Identifier | IPR030639 | Type | Family |
| Short Name | Praja-2 |
| description | Praja-2 belongs to the mammalian RING E3-ubiquitin ligase family and has E2-dependent E3 ubiquitin-protein ligase activity. It regulates the total concentration of protein kinase A (PKA) regulatory (Rs) subunits, tuning the strength and duration of PKA signal output in response to cAMP []. It binds to MOB1 (Mps one binder 1), a core effector of the Hippo pathway, and serves as an upstream regulator of the Hippo signalling, linking the ubiquitin proteasome system to deregulated glioblastoma growth []. Induces the ubiquitination of MFHAS1, which positively regulates the Toll-like receptor 2 signaling/c-Jun N-terminal kinase (JNK)/nuclear factor (NF)-kB pathway and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype []. |
