| Primary Identifier | IPR030631 | Type | Family |
| Short Name | RIM2 |
| description | The active zone is the presynaptic region in the nerve terminals that mediates neurotransmitter release and is composed a dense collection of proteins called the cytomatrix at the active zone (CAZ). The CAZ proteins are thought to mediate synapse formation and regulate neurotransmitter release [, ].RIM proteins are scaffolding proteins at the active zone which bind to several other presynaptic proteins. The long isoforms of RIM proteins, which contain N-terminal Rab3 and Munc13 interacting domains, as well as a central PDZ domain and two C-terminal C2 domains, are encoded by two genes, Rim1 and Rim2 []. They have multiple isoforms (alpha, beta, gamma) diverging in their structural composition, which mediate overlapping and distinct functions [, ]. These isoforms are involved in determining Ca2+ channel density and vesicle docking at the presynaptic active zone []. This entry represents regulating synaptic membrane exocytosis protein 2 (RIM2). RIM2alpha plays a critical role in insulin granule exocytosis []. |
