| Primary Identifier | IPR039032 | Type | Family |
| Short Name | Rim-like |
| description | RIM proteins are scaffolding proteins at the active zone which bind to several other presynaptic proteins. The long isoforms of RIM proteins, which contain N-terminal Rab3 and Munc13 interacting domains, as well as a central PDZ domain and two C-terminal C2 domains, are encoded by two genes, Rim1 and Rim2 []. They have multiple isoforms (alpha, beta, gamma) diverging in their structural composition, which mediate overlapping and distinct functions [, ]. These isoforms are involved in determining Ca2+ channel density and vesicle docking at the presynaptic active zone []. This entry includes Rim and related proteins. In Caenorhabditis elegans Rim acts after vesicle docking likely via regulating priming []. |
