| Primary Identifier | IPR039027 | Type | Family |
| Short Name | RAC_alpha |
| description | Protein kinase B (PKB), also called Akt or RAC, is a phosphatidylinositol 3'-kinase (PI3K)-dependent Ser/Thr kinase which alters the activity of the targeted protein []. Akt regulates numerous cellular processes, including cell growth, differentiation, proliferation, apoptosis, and glucose metabolism. Among its many roles, Akt appears to be common to signaling pathways that mediate the metabolic effects of insulin in several physiologically important target tissues [, ]. Human Akt has three isoforms derived for distinct genes: Akt1/PKBalpha, Akt2/PKBbeta, and Akt3/PKBgamma.This entry includes the isoforms alpha. Akt1 and Akt2 have distinct functions; they are involved in the control of growth and metabolism, respectively [, ]. |
