| Primary Identifier | IPR027036 | Type | Family |
| Short Name | SHOC2 |
| description | Leucine-rich repeat protein SHOC2 is a regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, it targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialised signaling complexes [, ]. In humans, defects in SHOC2 are the cause of Noonan syndrome-like disorder with loose anagen hair (NSLH) []. In Caenorhabditis elegans the homologue is known as Soc2 []. |
