| Primary Identifier | IPR030483 | Type | Family |
| Short Name | Nhp10 |
| description | This entry represents non-histone protein 10 (Nhp10, also known as Hmo2) from fungi. Nhp10 is a subunit of the non-essential INO80 chromatin remodelling complex, which contributes to transcription, DNA repair and DNA replication []. The interaction between Nhp10 and the DNA damage-induced phosphorylated histone H2A (gamma-H2AX) is required to recruit INO80 complex to a HO endonuclease-induced double-strand break []. Nhp10 binds to DNA ends and protect them from exonucleolytic cleavage []. It is related to the high-mobility group B (HMGB) proteins from mammals []. |
