| Primary Identifier | IPR042460 | Type | Homologous_superfamily |
| Short Name | DCN1-like_PONY |
| description | This superfamily represents a domain is found in DCN1-like proteins. Proteins of the DCN family may contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes, which are multi-protein complexes required for polyubiquitination and subsequent degradation of target proteins by the 26S proteasome [, ].The structure of this domain is composed entirely of alpha helices [, ]. It has been referred to as potentiating neddylation domain (PONY) and can be found in association with an N-terminal UBA domain. The PONY domain contains a cullin-binding surface within its C-terminal region and is sufficient to promote neddylation [, ]. |
