| Primary Identifier | IPR030486 | Type | Family |
| Short Name | DNMT3L |
| description | DNA (cytosine-5)-methyltransferase 3-like (DNMT3L) is an enzymatically inactive regulatory factor of de novoDNA methyltransferases DNMT3A and DNMT3AB [, , ]. It is related in sequence to DNMT3A and DNMT3B, but lacks cytosine methyltransferase activity due to the absence of catalytic residues. It recognises histone H3 tails that are unmethylated at lysine 4 and induces de novo DNA methylation by recruitment or activation of DNMT3A2 []. It interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences []. In mouse embryonic stem cells, DNMT3L functions as a negative regulator of methylation at promoters of bivalent genes whereas favours DNA methylation at gene bodies of housekeeping genes []. |
