| Primary Identifier | IPR030460 | Type | Family |
| Short Name | Envoplakin |
| description | Envoplakin belongs to the plakin family of cytolinker proteins, which also includes desmoplakin, plectin, periplakin and BPAG1 (bullous pemphigoid antigen) []. It was originally identified as components of the cornified envelope (CE) [, ]. It is also found in the desmosomes of keratinocytes and other epithelial cells []. Envoplakin and periplakin can form stable heterodimers that localise to desmosomes and the plasma membrane in a manner dependent on the periplakin N terminus []. The C termini of envoplakin and periplakin bind intermediate filaments, and this interaction may provide the link between the cytoskeleton and the CE that confers mechanical stability to corneocytes [, ]. |
