| Primary Identifier | IPR042491 | Type | Homologous_superfamily |
| Short Name | Vps35_C |
| description | This superfamily represents the α-helical C-terminal domain found in vacuolar protein sorting-associated protein 35 (Vps35) from eukaryotes.Vps35 is a core component of the retromer complex which functions in the endosome-to-Golgi retrieval cargo transport pathway [, ]. Vps35 is part of the a cargo-selective complex trimer (CSC) of the retromer, which is composed of Vps26, Vps29 and Vps35 and is responsible for binding to and sorting protein cargo []. Mutations in the Vps35 gene have been linked to Parkinson's disease []. Structurally, VPS35 forms a horseshoe-shaped, right-handed, α-helical solenoid []. |
