| Primary Identifier | IPR030520 | Type | Family |
| Short Name | SH2B2 |
| description | SH2B adapter protein 2 (SH2B2, also known as APS) belongs to the SH2B family of adapter proteins []. SH2B2 is involved in multiple signalling pathways, includingcytokine signalling and insulin receptor signalling [, ]. It also binds to Vav3, a member of the vav proto-oncogene family, and increases its activity [].SH2B family contains three members of adaptor proteins: SH2B1, 2 and 3 []. Typical SH2B proteins contain a SH2 (Src homology 2) and a PH (pleckstrin homology) domain. They serve as adaptors involved in signalling by the receptors for growth factors, such as insulin-like growth factor 1, platelet-derived growth factor and nerve growth factor []. |
