| Primary Identifier | IPR037884 | Type | Domain |
| Short Name | LARG_RGS |
| description | The RGS domain is an essential part of the leukemia-associated RhoGEF protein (LARG, also known as Rho guanine nucleotide exchange factor 12), a member of the RhoGEF subfamily of the RGS protein family. The RhoGEFs are peripheral membrane proteins that regulate essential cellular processes, including cell shape, cell migration, cell cycle progression of cells, and gene transcription by linking signals from heterotrimeric G-alpha12/13 protein-coupled receptors to Rho GTPase activation, leading to various cellularresponses, such as actin reorganization and gene expression [, ].The RhoGEF subfamily includes p115RhoGEF, LARG, PDZ-RhoGEF, and its rat specific splice variant GTRAP48. The RGS domain of RhoGEFs has very little sequence similarity with the canonical RGS domain of the RGS proteins and is often refered to as RH (RGS Homology) domain []. In addition to being a G-alpha13 effector, the LARG protein also functions as a GTPase-activating protein (GAP) []. |
