| Primary Identifier | IPR029845 | Type | Family |
| Short Name | Nrf2 |
| description | Nuclear factor erythroid 2-related factor 2 (Nrf2) belongs to the CNC-bZIP family, which is a group of transcription factors that are activated in response to cellular stress. It binds to antioxidant response (ARE) elements in the promoter regions of target genes []. It is constitutively and ubiquitously expressed in a number of tissues and cell lines. When exposed to oxidative stress, the expression of Nrf2 increases, further driving the transcriptional activation of genes that control cellular redox homeostasis []. Nrf2 is regulated by the repressor protein Keap1, which acts by directly interacting with Nrf2 and preventing its nuclear accumulation []. Keap1 not only acts to retain Nrf2 in the cytoplasm but also actively promotes its ubiquitylation and subsequent degradation by the proteasome. |
