| Primary Identifier | IPR027053 | Type | Family |
| Short Name | ADAM_10 |
| description | Disintegrin and metalloproteinase domain-containing protein 10 (also known as ADAM10 or Kuzbanian; MEROPS identifier M12.210) is an endopeptidase () []. In humans and mice, it cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. It is responsible for the proteolytic release of several other cell-surface proteins. It controls the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis []. The Drosophila orthologue is classified separately in the MEROPS database as M12.211. |
