| Primary Identifier | IPR039078 | Type | Family |
| Short Name | GIP |
| description | Gastric inhibitory polypeptide or glucose-dependent insulinotropic polypeptide (GIP) is a hormone released from duodenal K cells in a glucose-dependent manner []. It is considered an incretin hormone as it stimulates the secretion of insulin in the presence of elevated glucose; the other incretin being glucagon-like peptide-1 (GLP-1). It acts through the GIP receptor (GIPR) expressed in pancreatic beta-cells []. GIP plays a role in glucose and lipid metabolism. It increases lipoprotein lipase (LPL) expression and activity, and promotes fatty acid incorporation and synthesis [, , ]. It is associated with obesity and insulin resistance [, ]. |
