| Primary Identifier | IPR035573 | Type | Domain |
| Short Name | SAM_PNT-FLI-1 |
| description | This is the SAM pointed domain of FLI-1 (Friend Leukemia Integration) subfamily of ETS transcriptional regulators. It is a putative protein-protein interaction domain. The FLI-1 protein participates in regulation of cellular differentiation, proliferation, and survival [, ]. The Fli-1 gene was initially described in Friend virus-induced erythroleukemias as a site for virus integration. It is highly expressed in hematopoietic tissues and at lower level in lungs, heart, and ovaries. Fli-1 is a proto-oncogene implicated in Ewing's sarcoma and erythroleukemia [, ]. Members of this family are potential targets for cancer therapy []. |
