| Primary Identifier | IPR003126 | Type | Domain |
| Short Name | Znf_UBR |
| description | It has been observed that the identity of N-terminal residues of a protein isrelated to the half life of the protein. This observation yields a rule,called the N-end rule []. Similar but distinct versions of the N-end rule operate in all organisms examined, from mammals to fungi and bacteria. Ineukaryotes, the N-end rule pathway is a part of the ubiquitin degradationsystem. Some proteins that have a very short half life contain a specificmotif at their N terminus, the N-degron. It consists of a destabilisingN-terminal residue and an internal Lys, which is the site of poly-Ub chain[, ].The UBR1 protein was shown to bind specifically to proteins bearing N-terminalresidues that are destabilising according to the N-end rule, but not tootherwise identical proteins bearing stabilising N-terminal residues []. UBR1 contains an N-terminal conserved region (the UBR-type zinc finger) which is also found in various proteins implicated in N-degron recognition. The UBR-type zinc finger defines a unique E3 class, most likely N-degron specific []. |
