| Primary Identifier | IPR042746 | Type | Domain |
| Short Name | EPH-A6_SAM |
| description | This entry represents the SAM (sterile alpha motif) domain of EPH-A6 (Ephrin type-A receptor 6), a receptor tyrosine kinase. It is a C-terminal potential protein-protein interaction domain located in the cytoplasmic region of EPH-A6 receptors and appears to mediate cell-cell initiated signal transduction []. Eph-A6 gene is preferentially expressed in the nervous system. EPH-A6 receptors are involved in primate retina vascular and axon guidance, and in neural circuits responsible for learning and memory []. EphA6 gene was significantly down regulated in colorectal cancer and in malignant melanomas. It is a potential molecular marker for these cancers [, ]. |
