| Primary Identifier | IPR045075 | Type | Family |
| Short Name | Syf1-like |
| description | This entry represents a group of pre-mRNA-processing factors, including Syf1/Clf1 from budding yeasts and protein crooked neck (CRN) from fruit flies. Syf1 acts as a component of the NTC complex (or Prp19-associated complex), associatesto the spliceosome to mediate conformational rearrangement or to stabilize the structure of the spliceosome after U4 snRNA dissociation, which leads to spliceosome maturation [, ]. Clf1 is a splicing factor that are part of at least two multisubunit protein complexes, a small nuclear RNA-free structure similar to what was reported as the Prp19 complex and an RNP structure that contains the U2, U5, and U6 small nuclear RNAs []. Human CRN-like protein is also implicated in pre-mRNA splicing [. The crn mutation in Drosophila has been shown to cause abnormalities in the central and peripheral nervous systems []. |
