| Primary Identifier | IPR030792 | Type | Family |
| Short Name | TPPP1 |
| description | TPPP1 (also known as TPPP/p25) belongs to the TPPP (tubulin polymerisation promoting protein) family []. TPPP/p25 binds to tubulins and cause microtubules (MT) bundling both in vitro and in vivo []. It promotes tubulin acetylation by inhibiting histone deacetylase 6 []. Its ability of assemble MTs can be inhibited by LIM kinase []. Rho-associated coiled-coil kinase (Rock) and Cdk phosphorylation of TPPP/p25 inhibits its regulation of the cell cycle to increase cell proliferation []. |
