| Primary Identifier | IPR039112 | Type | Family |
| Short Name | PID1 |
| description | PID1 (PTB-containing, cubilin and LRP1-interacting protein; also known as NYGGF4) is a phosphotyrosine-binding (PTB) domain-containing protein. It is an inhibitor of insulin-mediated signaling in adipocytes and muscle cells. It binds through its PTB domain to the second NPXY motif in the cytoplasmic tail of the low density lipoprotein receptor-related protein 1 (LRP1)[]. Besides being involved in obesity-associated insulin resistance [], PID1 has been shown to inhibit growth of medulloblastoma, glioblastoma and atypical teratoid rhabdoid tumour cell lines []. |
