| Primary Identifier | IPR015428 | Type | Family |
| Short Name | Synaptotagmin1 |
| description | Synaptotagmins are synaptic vesicle membrane proteins found in abundance in nerve cells and some endocrine cells [, ]. The amino acid sequence of synaptotagmin comprises a single transmembrane region with a short vesicular N-terminal region, and a cytoplasmic C-terminal region containing 2 internal repeats similar to the C2 regulatory domain of protein kinase C. The protein is believed to be important in the docking and fusion of synaptic vesicles with the plasma membrane, i.e. with neurotransmitter release [, ].Synaptotagmin 1 (originally called p65) and synaptotagmin 2 were the first to members identified in the synaptotagmin family [, ]. Synaptotagmin 1 may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse []. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone [, ]. It has been shown to function as a Ca2+ sensor on the synaptic vesicle surface, therefore to regulate Ca2+ dependent neurotransmitter release [, ]. |
