| Primary Identifier | IPR039477 | Type | Domain |
| Short Name | ILEI/PANDER_dom |
| description | This entry represents the ILEI/PANDER domain found in FAM3 family members and related proteins. Both PANDER and ILEI share a similar β-β-alpha fold, strikingly different from the classical cytokines [].FAM3C, also known as interleukin-like EMT inducer ILEI, is a secreted signaling protein involved in epithelial-mesenchymal transition and tumor progression [].FAM3B, also known as PANDER (PANcreatic DERived factor), is a cytokine-like protein that induces apoptosis of insulin-secreting beta-cells []and functions as a hormone by regulating glucose levels []. The fold of the stem domain of POMGnT1 (O-linked mannose beta1,2-N-acetylglucosaminyltransferase 1) resembles that of PANDER []. |
