| Primary Identifier | IPR017920 | Type | Domain |
| Short Name | COMM |
| description | COMM (copper metabolism gene MURR1) domain proteins constitute a family initially identified as interactingpartners of COMMD1 (previously known as MURR1), the prototype member of this protein family. COMMD1 is a multifunctional protein that has been shown to participate in two apparently distinct activities, regulation of the transcription factor NF-kappa-B and control of copper metabolism. The family is defined by the presence of a C-terminal motif termed COMM domain, which functions as an interface for protein-protein interactions. The proteins designated as COMMD or COMM domain containing 1-10 are extensively conserved in multicellular eukaryotic organisms [, ].The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a β-sheet []. |
