| Primary Identifier | IPR003327 | Type | Domain |
| Short Name | Myc-LZ |
| description | This family consists of the leucine zipper dimerisation domain found in both cellular c-Myc proto-oncogenes and viral v-Myc oncogenes. Dimerisation via the leucine zipper motif with other basic helix-loop-helix-leucinezipper (b/HLH/lz) proteins is required for efficient DNA binding []. The Myc-Maxdimer is a transactivating complex activating expression of growth related genes promoting cell proliferation.The dimerisation is facilitated via interdigitating leucine residues every 7th position of the alpha helix. Likecharge repulsion of adjacent residues in this region preturbs the formation of homodimers with heterodimersbeing promoted by opposing charge attractions. It has been demonstrated that in transgenic mice the balance between oncogene-induced proliferation and apoptosis in a given tissue can be a critical determinant in the initiation and maintenance of the tumor []. |
