| Primary Identifier | IPR025763 | Type | Family |
| Short Name | Trm8_euk |
| description | This entry represents the eukaryotic tRNA (guanine-N-7) methyltransferases catalytic subunit Trm8, and its homologue, such as METTL1 from humans []. In Saccharomyces cerevisiae, it forms the tRNA methyltransferase complex with Trm82 (WDR4 homologue in humans). This enzyme catalyses the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay. Both the D-stem and T-stem structures of tRNAs are required for efficient methyltransferase activity [, , ]. The function of Trm8 is regulated by Trm82 []. |
