Primary Identifier | IPR005991 | Type | Family |
Short Name | GUAB1-like |
description | This family of proteins restricted to the high GC Gram-positive bacteria includes GMP reductase from Mycobacterium smegmatis (GUAB1), which is involved in the purine-salvage pathway. This protein is composed of two domains: a catalytic domain with a TIM barrel structure and another that folds as a typical Bateman domain composed of two CBS domains (cystathionine-beta-synthase domain, CBS, ), which are essential for the NADPH-dependent conversion of GMP to IMP []. |