| Primary Identifier | IPR003349 | Type | Domain |
| Short Name | JmjN |
| description | This entry represents the JmjN domain.The JmjN and JmjC domains are two non-adjacent domains which have been identified in the jumonji family of transcription factors. Although it wasoriginally suggested that the JmjN and JmjC domains always co-occur and might form a single functional unit within the folded protein, the JmjC domain was later found without the JmjN domain in organisms from bacteria to human [, ].JmJC domains are predicted to be metalloenzymes that adopt the cupin fold, and are candidates for enzymes that regulate chromatin remodelling. The cupin fold is a flattened β-barrel structure containing two sheets of five antiparallel β-strands that form the walls of a zinc-binding cleft. JmjC domains were identified in numerous eukaryotic proteins containing domains typical of transcription factors, such as PHD, C2H2, ARID/BRIGHT and zinc fingers [, ]. The JmjC has been shown to function in a histone demethylation mechanism that is conserved from yeast to human []. |
