| Primary Identifier | IPR039334 | Type | Family |
| Short Name | PSMD10-like |
| description | The 26S proteasome is a large enzymatic complex (composed of the 20S core particle (CP) and the 19S regulatory particle (RP)) that degrades ubiquitinated proteins in eukaryotic cells [].This entry represents 26S proteasome non-ATPase regulatory subunit 10 (also known as Gankyrin or p28, gene name PSMD10, or NAS6 in yeast). Gankyrin was initially thought to be a subunit of the 19S RP, however it has since been shown to associate transiently with the RP, acting as a chaperone during proteasome assembly. Specifically, it has been shown to interact with 26S proteasome regulatory subunit 6B (RPT3, PSMC4) []. Gankyrin (an ankyrin-repeat protein) is also reported as an oncoprotein involved in hepatocarcinogenesis []. |
