| Primary Identifier | IPR039664 | Type | Family |
| Short Name | GRB/APBB1IP |
| description | Proteins in this entry consist of a Ras-associated (RA) domain, a PH domain, a family-specific BPS region, and a C-terminal SH2 domain. Grb7, Grb10 and Grb14 are paralogues that are also present in this entry []. These adapter proteins bind a variety of receptor tyrosine kinases, including the insulin and insulin-like growth factor-1 (IGF1) receptors. Grb10 and Grb14 are important tissue-specific negative regulators of insulin and IGF1 signaling based and may contribute to type 2 (non-insulin-dependent) diabetes in humans. RA-PH function as a single structural unit and is dimerized via a helical extension of the PH domain. The PH domain here are proposed to bind phosphoinositides non-cannonically and are unlikely to bind an activated GTPase []. This entry also includes APBB1IP (also known as RIAM), which functions in the signal transduction from Ras activation to actin cytoskeletal remodelling []. |
