| Primary Identifier | IPR001060 | Type | Domain |
| Short Name | FCH_dom |
| description | FCH domain is a short conserved region of around 60 amino acids first described as a region of homology between FER and CIP4 proteins []. In the CIP4 protein the FCH domain binds to microtubules []. The FCH domain is always found N-terminally and is followed by a coiled-coil region. The FCH and coiled-coil domains are structurally similar to Bin/amphiphysin/RVS (BAR) domains []. They are α-helical membrane-binding modules that function in endocytosis, regulation of the actin cytoskeleton and signalling []. Proteins containing an FCH domain can be divided in 3 classes []:A subfamily of protein kinases usually associated with an SH2 domain:Fps/fes (Fujimani poultry sarcoma/feline sarcoma) proto-oncogenes. They are non-receptor protein-tyrosine kinases preferentially expressed in myeloid lineage. The viral oncogene has an unregulated kinase activity which abrogates the need for cytokines and influences differentiation of haematopoietic progenitor cells.Fes related protein (fer). It is an ubiquitously expressed homologue of Fes.Adaptor proteins usually associated with a C-terminal SH3 domain:Schizosaccharomyces pombe CDC15 protein. It mediates cytoskeletal rearrangements required for cytokinesis. It is essential for viability.CD2 cytoplasmic domain binding protein.Mammalian Cdc42-interacting protein 4 (CIP4). It may act as a link between Cdc42 signaling and regulation of the actin cytoskeleton.Mammalian PACSIN proteins. A family of cytoplasmic phosphoproteins playing a role in vesicle formation and transport.A subfamily of Rho-GAP proteins:Mammalian RhoGAP4 proteins. They may down-regulate Rho-like GTPases in hematopoietic cells.Yeast RHO GTPase-activating protein RGD1 (also known as YBR260C).Caenorhabditis elegans hypothetical protein ZK669.1. |
