| Primary Identifier | IPR003690 | Type | Family |
| Short Name | MTERF |
| description | This entry represents the mitochondrial/chloroplastic transcription termination factors (MTERFs). In humans four MTERFs have been identified (MTERF1-4). MTERF1 was first identified as a factor responsible for terminating heavy strand transcription at a specific site at the leu-tRNA, thereby modulating the ratio of mitochondrial ribosomal RNA to mRNA []. Later, MTERF1 was found to stimulate transcriptional initiation []and appeared to be in the control of mitochondrial replication pausing []. From a structural study, it binds to dsDNA containing the termination sequence and unwinds the DNA molecule, promoting base eversion, which is critical for transcription termination []. |
