| Primary Identifier | IPR039686 | Type | Family |
| Short Name | FANCM/Mph1-like |
| description | This entry includes a group of evolutionarily conserved ATP-dependent DNA helicases/translocases including human FANCM (Fanconi anemia group M protein) and its homologues, such as Mph1 from S. cerevisiae and Fml1/2 from S. pombe. FANCM is part of the FA complex that repair the interstrand cross-linking (ICL) lesions and coordinates activities of the downstream DNA repair pathway including nucleotide excision repair, translesion synthesis, and homologous recombination []. It also plays a critical role in the replication stress response []. Mph1 can unwind Rad51 D-loops and extended D-loops []. It has been shown to be regulated by the Smc5/6 complex [, ]. Fml1 promotes Rad51-dependent gene conversion at stalled/blocked replication forks and limits crossing over during mitotic double-strand break repair [, ]. |
