| Primary Identifier | IPR039674 | Type | Family |
| Short Name | FLASH |
| description | CASP8-associated protein 2 (CASP8AP2), also known as FLASH, is involved in various cellular functions, such as cell cycle progression, transcriptional regulation, the regulation of apoptosis, and the regulation of histone gene expression []. It is an essential component of Cajal bodies and is involved in the apoptosis receptor signaling pathway [].FLASH contains the N terminus required for histone pre-mRNA processing, the C-terminal segment which forms a SANT/Myb-like domain, and a small central region which binds Ars2 essential for cell cycle progression []. Its N-terminal domain has been found to form a 2:1 heterotrimer with Lsm11 for histone pre-mRNA 3'-end processing []. |
