| Primary Identifier | IPR003518 | Type | Family |
| Short Name | Sal_SpvA |
| description | Salmonella typhimurium contains a 90kb plasmid that is associated withvirulence. This plasmid encodes at least 6 genes needed by thebacterium for invading host macrophages during infection. These includethe 70kDa mkaA protein [], a recognised virulence factor, and more recently described, four spv genes under the control of a regulator [].Deletion studies on the virulence plasmid have shown that an open reading frame encoding a 28kDa protein was needed for successful invasion of the host. This protein, designated mkfA [], VRP4 []or VirA []by differentgroups, is utilised by the microbe upon entry into macrophages, although the exact mechanism is unclear. |
