| Primary Identifier | IPR003550 | Type | Family |
| Short Name | Claudin4 |
| description | Claudins form the paracellular tight junction seal in epithelial tissues. In humans, 24 claudins (claudin 1-24) have been identified. Their ability to polymerise and form strands is affected by the cell types [, , ]. They can also form heteropolymers with each other within and between tight junction strands []. Most of the claudins (claudin-12 being the exception) have a C-terminal PDZ-binding motif that can interact with other PDZ domain proteins, such as scaffolding protein, ZO-1, -2 and -3 []. They also interact with non-tight junction proteins, such as cell adhesion proteins EpCam and tetraspanins and the signaling proteins, ephrin A and B and their receptors, EphA and EphB [].Claudin-4 was originally termed Clostridium perfringens enterotoxin receptor (CPE-R). It was reclassified as claudin-4 on the basis of cDNA sequence similarity with claudins-1 and -2, and antibody studies thatshowed it to be expressed at tight junctions []. |
